But what if the antidepressants also blocked insulin? In a study (Mol
Cell Neurosci. 2007 Nov;36(3):305-12) researchers found that the most common antidepressants did just that. So it should not be surprising that a study on diabetes and antidepressant use found that:
“Long-term use of antidepressants in at least moderate daily doses was associated with an increased risk of diabetes. This association was observed for both tricyclic antidepressants and selective serotonin reuptake inhibitors. (Am J Psychiatry. 2009 May;166(5):591-8.)”
If antidepressants like Prozac, Zoloft, and the rest all had a long history of working against depression we have one benefit against another side effect. But when you look for the studies about these widely used drugs we find:
“No RCTs addressing the efficacy of maintenance treatment with antidepressants as compared to placebo were performed in primary care. Recommendations on maintenance treatment with antidepressants in primary care cannot be considered evidence-based.” (Eur J Gen Pract. 2010 Jun;16(2):106-12.)
If we haven’t done the studies to justify the medications, what are we basing the recommendations of continued use of antidepressants upon?
The research, overwhelmingly funded by the manufacturers of the antidepressants, doesn’t show the sort of dramatic effect we would expect from a massive branch of pharmaceuticals. When matched against placebos that produce side effects, antidepressants do little.
“The more conservative estimates from the present analysis found that differences between antidepressants and active placebos were small. This suggests that unblinding effects may inflate the efficacy of antidepressants in trials using inert placebos” Cochrane Database Syst Rev. 2004;(1):CD003012
None of the studies go long enough. “We suggest that current methodology has been unsuccessful in achieving unbiased double-blind conditions not influenced by extra-trial factors, including time.” Ann Pharmacother. 2003 Dec;37(12):1891-9
Let me summarize: we have very little evidence to support decades-long prescriptions for antidepressants and mounting evidence that these prescriptions may be increasing diabetes.
For more studies on this and possible alternatives, go to:
- Weight Gain and Antidepressants (everydayhealth.com)
- Coping With Antidepressant Side Effects (everydayhealth.com)
- America’s Zoloft Problem (thedailybeast.com)
- The Problem With an Antidepressant-Addicted America (health.wealthwire.com)
- Following the evidence (addictionandrecoverynews.wordpress.com)
- Depressingly Ineffective (lewrockwell.com)
- Zoloft Birth Defect Lawsuits Being Filed Around the Country (prweb.com)
- GPs hand out record 47m Antidepressant prescriptions… a rise of 9% in a year (engineeringevil.com)
- Prozac : 50% Placebo Effect? (try-therapy.com)
- Rx Pills Making You Fat? (foxnews.com)