Posted by: Chris Maloney | June 10, 2012

If You Don’t Want To Diet And Don’t Exercise, Can You Really Lose Weight On Resveratrol?

Ahhh... Wine

Ahhh… Wine (Photo credit: mRio)

The title of the magazine article was a definite tease:  Don’t Want to Diet and Don’t Exercise and Lose Eight Pounds a Week.

I have a generalized notice to all weight loss folks:  when they give a specific weight, rather than an “average” weight, they are not talking about any study under the sun.  Nobody runs a study where everyone loses eight pounds a week.   Some people lose nothing, some people lose sixteen pounds.

The article went on to say that this miracle substance would prevent diabetes.  And cancer!  Amazing stuff.  What is it?  Resveratrol.

If you felt a little let down, so did I.  I was looking for another Sudanese hill plant, or an upper Siberian lichen that only grows on Snow Leopard droppings.  Something unusual.  But in due diligence, I looked up what the newest information on Resveratrol was.

If you happen to be a mouse with drug-induced diabetic changes, then the combination of Resveratrol and ferulic acid (injected) will undo the oxidative damage and restore the antioxidant levels of your organs.  What we can say this says about humans taking oral Resveratrol is almost nothing.  But “Mouse study shows antioxidant effects of injected Resveratrol” doesn’t sell magazines.

Now, Resveratrol does seem to help as an antioxidant.  We see some nice changes of lowering inflammation markers in a manufacturer study of heart patients.  (abstract below).

We also see some changes in fat metabolism when Resveratrol is given to mice.  But we have no human studies on weight loss.

Resveratrol is a potent antioxidant with some specific uses and it works well synergistically with other phytochemicals.  It doesn’t cause weight loss by itself, but it’s worth considering with your doctor if you are a diabetic heart patient looking to supplement for health.

Mol Nutr Food Res. 2012 May;56(5):810-21. doi: 10.1002/mnfr.201100673.

Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial.


Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Murcia, Spain.



The cardioprotective role of resveratrol as part of the human diet is not yet clear. Our aim was to investigate the effect of a grape supplement containing 8 mg resveratrol in oxidized LDL (LDLox), apolipoprotein-B (ApoB), and serum lipids on statin-treated patients in primary cardiovascular disease prevention (PCP).


A triple-blind, randomized, placebo-controlled trial was conducted. Seventy-five patients (three parallel arms) consumed one capsule (350 mg) daily for 6 months containing resveratrol-enriched grape extract (GE-RES, Stilvid®), grape extract (GE, similar polyphenolic content but no resveratrol), or placebo (maltodextrin). After 6 months, no changes were observed in the placebo group and only LDL cholesterol (LDLc) decreased by 2.9% (p = 0.013) in the GE group. In contrast, LDLc (-4.5%, p = 0.04), ApoB (-9.8%, p = 0.014), LDLox (-20%, p = 0.001), and LDLox/ApoB (-12.5%, p = 0.000) decreased in the Stilvid® group, whereas the ratio non-HDLc (total atherogenic cholesterol load)/ApoB increased (8.5%, p = 0.046). No changes were observed in hepatic, thyroid, and renal function. No adverse effects were observed in any of the patients.


This GE-RES reduced atherogenic markers and might exert additional cardioprotection beyond the gold-standard medication in patients from PCP. The presence of resveratrol in the GE was necessary to achieve these effects.

© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID:  22648627



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